Gastropell Daily Paste 5 x 30ml

Description

Gastropell Daily
Enteric coated Omeprazole in an oral paste for the treatment and prevention of gastric ulcers in horses.

ACTIVE CONSTITUENTS
Omeprazole 50mg/mL as an Oral Paste
Gastropell Daily contains omeprazole, a dose-dependant inhibitor of gastric acid secretion. Clinical trial data indicates that Gastropell Daily will inhibit gastric acid secretion to maintain gastric acidity at a non-aggressive level, which allows existing ulcers to heal within two weeks of commencing treatment, and that a reduced daily dose will prevent the recurrence of ulcers.
PACK SIZE
Pack of 5 x 30mL Adjustable dose syringes (three daily doses per syringe)
ACTIONS
Omeprazole is an inhibitor of gastric acid secretion. When given on a daily basis, omeprazole inhibits the enzyme system regarded as the acid (proton) pump within the gastric mucosa of the stomach by binding to the enzyme and blocking the first step of acid production.
Even though it is dosed orally, Gastropell Daily does not act directly on the stomach fluid as it is ingested. The drug passes through the stomach to the small intestine, where it is absorbed and travels via the bloodstream to the acid secreting cells of the stomach.
The powerful antisecretory effect of Gastropell Daily causes a dramatic reduction in the acidity of stomach fluid within days of commencing treatment, and because the gastric fluid is no longer irritating to the stomach lining, ulcers then heal spontaneously within two weeks. Continuation with reduced daily dosing then prevents ulcers from recurring.
INDICATIONS
The lower region of the stomach is permanently exposed to gastric acid and has a prostaglandin protective mechanism, which guards against acid attack. The squamous mucosa in the upper region of the stomach has, however, no inherent protection and frequent splashing with gastric acid fluid soon erodes the lining to cause spot lesions, which can develop into deep haemorrhaging ulcers within weeks.
For the stabled performance of horse given two or three feeds a day, the stomach is left for long periods without ingestion of feed and without the mat of ingesta on the surface of the stomach fluid that helps to contain the acidic fluid. This exposure to acid is then increased during intense exercise when the stomach volume is reduced to half that of the rested horse and the gastric acid is forced into the squamous region where it attacks the stomach lining.
The stomach lining is in a continual process of erosion and repair depending on the acidity of the stomach fluid and the horse/s feeding and exercise pattern.
The pattern of regular sessions of intense training and long periods of the day without ingestion of feed is, however, well tolerated by the performance horse in training if gastric acid secretion is blocked by Gastropell Daily – every day – and the gastric fluid is then not aggressive to the stomach lining.
DOSAGE AND ADMINISTRATION
PRECAUTIONS – If used on performance animals, regulations of relevant authorities regarding medication should be observed.
Dosage and administration: Give orally via syringe.
rtions within 3 days after completion of the treatment program.
Foals – 2 mL/100 kg BW (1.0 mg/kg BW) once daily as directed by a veterinarian.
Adult Horses – Treatment Dose – 10 mL/500 kg BW (1.0 mg/kg BW) once daily for two weeks followed by daily maintenance dosing.
Maintenance Dose – 5 mL/500 kg BW (0.5 mg/kg BW) once daily while horses remain in training, or as directed by a veterinarian.
Gastropell Daily 10 mL/500 kg BW can provide rapid healing of stomach ulcers while horses remain in training, which may be associated with the improvement in clinical signs within two weeks of commencing treatment.
When left untreated, ulcers can recur within two weeks with a severity and across an area equivalent to that prior to treatment. Available data indicates that regular daily maintenance dosing at a reduced rate prevents the recurrence of ulcers.
TIPS
If there is concern regarding development of gastric ulcers while phenylbutazone is being  administered, it is safe to concurrently administer Omeprazole as Gastropell Daily oral paste to prevent ulcer formation during phenylbutazone therapy. The pattern of regular sessions of  intense training and long periods of the day without ingestion of feed is well tolerated by horses in training if gastric acid secretion is blocked by Gastropell Daily every day. It is recommended  that stabled horses have access to roughage (hay) at all times so that chewing and salivation are stimulated. This produces saliva, which also acts to neutralise gastric acid. In addition, hay remains in the stomach for much longer periods than does grain or concentrate, thus reducing the time the stomach is empty. The stomach produces gastric acid constantly, yet this acid is only naturally neutralised by saliva, which is only produced when horses chew food.
NOT TO BE USED in horses intended for human consumption.
RACING/EVENT WITHHOLDING PERIOD
If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.